456 Pluripotent stem cell differentiation to osteogenic and chondrogenic precursor cells.

Differentiation of human pluripotent stem cell- derived mesenchymal progenitors into osteogenic, chondrogenic and adipogenic lineages

Review Paper: Embryonic Stem Cell and Osteogenic Differentiation

Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cell...

epigenetic regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in culture

management of mesenchymal stem cells (mscs) capabilities to differentiate into osteogenic and chondrogenic lineages would be of utmost importance for their future use in difficult to treat cases of destroyed bone and cartilage. thus, an understanding of the epigenetic mechanisms as important modulators of stem cell differentiation might be useful. epigenetic mechanism refers to a process that r...

The potential of human-derived periodontal ligament stem cells to osteogenic differentiation: An In vitro investigation

Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of patient’s teeth were cultured with Dex (0....

Composite Nanoscaffolds Modified with Bio-ceramic Nanoparticles (Zn2SiO4) Prompted Osteogenic Differentiation of Human Induced Pluripotent Stem Cells

Nanofiber scaffolds and bio-ceramic nanoparticles have been widely used in bone tissue engineering. The use of human induced pluripotent stem cells (hiPSCs) on this scaffold can be considered as a new approach in the differentiation of bone tissue. In the present study, a polyaniline-gelatin-polycaprolactone (PANi-GEL-PCL) composite nanoscaffold was made by electrospinning and modified superfic...